aerosy: PLEASE! Make this happen!
You did it with fallout 4, now why not rdr2? Rdr2 world is a little bit more empty to compare with fallout 4, Could actually be easier with rdr2!
How empty the game is is really irrelevant when talking about a Total Conversion. But a few things:
Bethesda had released their mod kit that is very full featured. Once the assets are made, it is less of an issue ot create the game spaces and use the existing systems to thier advantage to make a game.
As was stated, FO London is a fan-made project after years of work, much like Nehrim and Enderal for Oblivion and Skyrim repsectively.
RDR 2 isn't sold on GOG.
RDR2 has no such mod kit, has no such project in the works.
BUT GOOD NEWS! You could always start a TC project for a game like RDR 2.