There are games I played A LOT for some length of time, but I never go back to them: Civ IV, for example. But then there are games I keep coming back to year after year, after long breaks or short breaks, and I usually keep them installed.
Oblivion - It's the mods that keep me. I love the modding community. I love the labor of finding, installing, configuring and troubleshooting. I love pushing it too far and then having it all fall apart and starting over. I've never followed the main quest past getting Martin to Cloud Ruler Temple, and that just once. 5 years now...
Arcanum - It dropped off this past year, but I found it so rich. I can be so many different types of character. About 5 years of playing...
Deus Ex - In fact, I just reinstalled it last night!
Cheers.