For some reason it's escaping me. It's an old space shooter that had a primary antagonist that was like a circular enemy, much larger than you, that had a face and was primarily colored gray and red.

That's about all I can remember but it is a pretty distinctive game.

Sinistar?
http://www.sinistar.com/origsin.html

That's it. Thanks a ton. Spent a ton of time searching lists up and down for that. xD