Nosferatu (1922) would be really interesting in Vampire: Bloodlines. I mean, he's like the original elder Primogen of history, a Kain-esque figure in their clan mythos. But could he tango with the duplicity of those modern LA vamps? Is he really powerful? What about the half-senile fossil Nosferatu in Shadow of the Vampire (2000)?
Peter Colt, the aging tennis pro played by Paul Bettany in "Wimbledon" (2004) I don't think would have as much a fairy tale run at the Wimbledon in "Top Spin 2". Somehow I see Roger Federer, Andy Roddick, and Lleyton Hewitt rather easily dominating him. And in Top Spin 4 you could add Nadal, Murray, & Djokovic to that roster.
Audrey Tatou ala Amelie (2001) would do great in The Longest Journey. They have the same hair-cut and all.
Clive Owen's character Jack Manfred in Croupier (1998) would do just fine in the Thief series. Good with his hands, observant, calculating, as glib as Garrett as uses just as few words most of the time. Plus, Clive Owen's
Been in Video Games Before.
Jesse James (take your pick Movie-wise; I vouch for Assassination of Jesse James by the Coward Robert Ford - 2007) would do just fine in Sid Meier's Pirates!
And I'm going with Viggo Mortesson's character from the Road (2009) in Fallout. Considering the
Cannibal Holocaust the man puts up with in that film, water chips in the wasteland have to be a piece a cake. Plus, he has the Doctor perk.
Any of the auto-erotic "specialists" in David Cronenberg's Crash (1996) in the Need for Speed games. No fear of collisions there!
Johnny Depp's Frederick Abberline (From Hell, 2001) in Post Mortem.
And finally, Judy Garland's Dorothy (Wizard of Oz, 1939. Duh.) in Arcanum. I mean, with her high Beauty and Charisma scores, she can just cruise through the game with all her Troika (get it?) of followers taking on all comers.