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Ional: Ok, if you disabled Malwarebytes that shouldn't be the problem.

I've heard that it is best to install outside the standard 'Program Files' folder. I don't think it should matter when you run as administrator, but I would give it a go: reinstall (or move, that might work) files to a directory outside the 'program files' folder, like maybe C:\Games\NWN, and try again.
I hope it helps, ... If not i'm at a loss.

And, btw, the latest patch you installed was the 'Critical Rebuild Patch 1.69', right?

edit:
I found this thread on the official forum. It has some info on trouble-shooting the installation.
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Th0rx669: The different install locations didn't work :/
And for some reason, I could run the disk version, but it had to close because of a compatibility issue with windows 7. I then updated it, and had the same problem as the gog version, with the 1.69 patch. It actually stopped working when I tried to 1.66 patch, and 1.68 didn't work either.

And I've tried pretty much everything in that thread :/
Please write to our Support department and please make sure to attach a DxDiag along with your email and we'll do our best to help you out in your predicament.
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JudasIscariot: Please write to our Support department and please make sure to attach a DxDiag along with your email and we'll do our best to help you out in your predicament.
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Th0rx669: What's a DxDiag?
http://en.wikipedia.org/wiki/DxDiag

That explains it much better than I can. However, when I refer to a DxDiag file, I am referring to the text file you get when you click on the "Collect System Information" tab in the Direct X Diagnostics program. To access it, just type DxDiag in the Windows Run bar when you press the Start button.